Progress of T-cell immunodeficiency and immunotherapy in chronic lymphocytic leukemia

VernacularTitle:T细胞免疫缺陷和免疫疗法在慢性淋巴细胞白血病中的研究进展
Author: Lu LIU ¹ ; Yujie WU
Author Information

1. 南京医科大学第一附属医院　江苏省人民医院血液科，南京　210029
Keywords: Leukemia, lymphocytic, chronic; T cells; Immunodeficiency; Immunotherapy; Tumor microenvironment
From: Journal of Leukemia & Lymphoma 2023;32(7):439-442
CountryChina
Language:Chinese
Abstract: The occurrence and development of chronic lymphocytic leukemia (CLL) are related to many factors such as CLL cells, defective T cells and tumor microenvironment. The mutual interaction between tumor cells and immune cells in tumor microenvironment is an important factor for the progress of CLL. T cells, as the main members of adaptive immunity, play an ambiguous role in CLL. This review focuses on the immunodeficiency of T-cell subsets in CLL and recent advances in T-cell immunotherapy, in order to explore the potential role of T cells in the occurrence, development and outcome of CLL.