Progress of single-cell sequencing in lymphoma

VernacularTitle:单细胞测序在淋巴瘤中的研究进展
Author: Jiapeng YANG ¹ ; Rui DONG ; Xiaowen ZHAI
Author Information

1. 国家儿童医学中心　复旦大学附属儿科医院血液科，上海　201102
Keywords: Lymphoma; Single-cell sequencing; Tumor heterogeneity; Tumor microenvironment; Precision treatment
From: Journal of Leukemia & Lymphoma 2023;32(7):435-438
CountryChina
Language:Chinese
Abstract: Single-cell sequencing (SCS) sequences the genetic information of a single cell to better understand the differences amongst cells and reveal the unique changes of each cell type. The specific analysis of cell subsets at the single-cell level can accurately evaluate tumor cells and microenvironment cells to reveal the complexity of molecular components and the difference from the corresponding components in non-malignant tissues. Lymphoma is highly heterogeneous, some have unknown pathological types, etiology and poor prognosis. SCS is helpful to clarify the molecular mechanisms of lymphomagenesis and pathological staging, and guide clinical practice. This article reviews SCS and its application in lymphoma.