Progress of tumor suppressor genes MLL3 in leukemia

VernacularTitle:肿瘤抑制基因MLL3在白血病中的研究进展
Author: Xue WANG ¹ ; Caihong XING
Author Information

1. 中国疾病预防控制中心职业卫生与中毒控制所/化学安全与健康重点实验室，北京　100050
Keywords: Leukemia, myeloid, acute; Hematopoietic stem cell transplantation; Lysine methyltransferase 2D gene
From: Journal of Leukemia & Lymphoma 2023;32(6):381-384
CountryChina
Language:Chinese
Abstract: MLL3 is also known as lysine methyltransferase 2C (KMT2C). The mutation of MLL3 can occur in a variety of human cancers, including leukemia, liver cancer, and stomach cancer. The effect of MLL3 in different cancers is also different, for example, MLL3 is carcinogenic in pancreatic and liver cancer, while it acts as a tumor suppressor in acute myeloid leukemia and esophageal squamous cell carcinoma. The effects of genes in tumors depend on certain environment and conditions, and the mechanism of the suppressive effect of MLL3 in leukemia is still not clear. This paper reviews the research progress of the antitumor mechanism of MLL3 in leukemia.