Graft-versus-host disease accompanied with new T-cell receptor genes clonal rearrangement after allogeneic hematopoietic stem cell transplantation: report of 2 cases and review of literature
10.3760/cma.j.cn115356-20220914-00258
- VernacularTitle:异基因造血干细胞移植后发生移植物抗宿主病伴新的T细胞受体基因克隆性重排2例并文献复习
- Author:
Nuo XU
1
;
Xiangli CHEN
;
Yuzhu ZANG
;
Yuqi LIN
;
Zhenghong WEI
Author Information
1. 河南大学人民医院血液科，郑州 450003
- Keywords:
Hematopoietic stem cell transplantation;
Graft versus host disease;
Gene, T-cell receptor;
Gene rearrangement
- From:
Journal of Leukemia & Lymphoma
2023;32(6):352-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of graft-versus host disease (GVHD)accompanied with new T-cell receptor (TCR) genes clonal rearrangement after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods:The clinical data of 2 patients admitted to People's Hospital of Henan University from December 2018 to March 2020 who developed GVHD after allo-HSCT accompanied with TCR genes clonal rearrangement were retrospectively analyzed, and the related literatures were reviewed.Results:Patient 1 was diagnosed with peripheral T-cell lymphoma non-specific type (PTCL-NOS), and then developed severe acute GVHD (aGVHD) after identical sibling allo-HSCT, and gradually developed liver chronic GVHD (cGVHD), skin cGVHD and new TCR genes clonal rearrangement. Patient 2 was diagnosed with acute myeloid leukemia (AML)-M 4, and severe aGVHD, hepatic cGVHD, and clonal rearrangement of TCR genes were gradually detected after identical sibling allo-HSCT. Conclusions:The TCR genes clonal rearrangement after allo-HSCT is not necessarily suggestive of tumors, and it may be related to lymphocyte development disorder caused by GVHD, so the comprehensive judgement should be carefully made.
