Progress of exosomes in drug resistance of hematologic malignancies

VernacularTitle:外泌体在恶性血液肿瘤耐药中的研究进展
Author: Lin QI ¹ ; Rui WANG ; Jianzhu FU ; Zhiyong CHENG
Author Information

1. 石家庄市第四医院内科，石家庄　050000
Keywords: Exosomes; Hematologic neoplasms; Drug therapy, combination; Drug resistance
From: Journal of Leukemia & Lymphoma 2023;32(5):314-317
CountryChina
Language:Chinese
Abstract: The incidence of hematologic malignancies is increasing, and although new drugs and treatments have made great progress, relapse and drug resistance are still urgent problems to be solved. Exosomes are tiny membrane vesicles secreted in cells that carry lipid bilayer membrane structures including mRNA, microRNA and proteins. It carries and transmits important signaling molecules, forming an entirely new intercellular information transfer system that exhibits a wide range of biological properties and functions in organisms. Tumor cell exosomes are confirmed to contribute to cancer cell proliferation, angiogenesis, invasiveness, distant metastasis and drug resistance. Multiple studies have shown that exosomes from some malignant hematological tumor cells are closely related to tumor resistance. This review summarizes the research progress of exosomes in the mechanism of drug resistance of hematologic malignancies, in order to provide a theoretical basis for the clinical treatment of hematologic malignancies.