CAG stimulating regimen in treatment of adult early T cell precursor acute lymphoblastic leukemia complicated with fusarium infection: report of 1 case and review of literature
10.3760/cma.j.cn115356-20220601-00159
- VernacularTitle:CAG预激方案治疗合并镰刀菌感染的成年人早期前体T细胞急性淋巴细胞白血病1例并文献复习
- Author:
Cong WANG
1
;
Gaoling ZHANG
;
Zhonghua DU
;
Wei HAN
;
Xiaoxia ZHAO
;
Sujun GAO
;
Qiuju LIU
Author Information
1. 吉林大学第一医院血液科，长春 130021
- Keywords:
Leukemia, T lymphocyte, acute;
Fusarium;
Recidivism;
Drug therapy, combination
- From:
Journal of Leukemia & Lymphoma
2023;32(3):166-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of CAG stimulating regimen for refractory adult early T cell precursor acute lymphoblastic leukemia (ETP-ALL) complicated with fusarium infection and the clinical features as well as antifungal strategy of cutaneous fusarium infection.Methods:The diagnosis and treatment of 1 adult patient diagnosed as ETP-ALL complicated with cutaneous fusarium infection in the First Hospital of Jilin University in September 2020 were retrospectively analyzed, and related literatures were reviewed.Results:VICP chemotherapy regimen showed no effectiveness in this patient who was presented with persistent agranulocytosis complicated with cutaneous fusariosis infection. After amphotericin B therapy for infection, he achieved the stable disease and successfully underwent CAG stimulating regimen salvage treatment. The minimal residual disease turned into negative after consolidation chemotherapy based on the myeloid regimen. Finally this patient survived from haploid allogeneic hematopoietic stem cell transplantation after consolidation chemotherapy and fusarium was under the control by using posaconazole as secondary prevention therapy.Conclusions:CAG stimulating regimen can be recommended as reinduction therapy for relapsed/refractory ETP-ALL. Sequential therapy of amphotericin B followed by posaconazole can be a useful antifungal strategy for fusarium infection.
