Primary bone lymphoma in children: report of 11 cases and review of literature
10.3760/cma.j.cn115356-20220326-00089
- VernacularTitle:儿童原发性骨淋巴瘤11例并文献复习
- Author:
Ziqing FENG
1
;
Yanlong DUAN
;
Ling JIN
;
Libing FU
;
Ningning ZHANG
;
Yonghong ZHANG
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院儿童肿瘤中心肿瘤内科 儿童血液病与肿瘤分子分型北京市重点实验室 儿科重大疾病研究教育部重点实验室，北京 100045
- Keywords:
Lymphoma;
Bone neoplasms;
Child;
Clinical features;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2023;32(1):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical manifestations, pathological features, treatment and prognosis of primary bone lymphoma in children.Methods:The clinical data of children who were initially diagnosed as primary bone lymphoma and treated in Beijing Children's Hospital Affiliated to Capital Medical University from January 2016 to January 2020 were retrospectively analyzed, including gender, onset age, primary involvement site, clinical stage, pathological type, fracture, and clinical outcome. The related literature was reviewed.Results:All 11 children were initially diagnosed as primary bone lymphoma, with a median age of onset of 8.6 years old (2.7-12.3 years old), including 7 males and 4 females. There were 7 cases of diffuse large B-cell lymphoma (DLBCL), 3 cases of B lymphoblastic lymphoma (BLL), and 1 case of anaplastic large cell lymphoma (ALCL). The initial symptoms were bone pain in 8 cases, local swelling in 1 case, limp in 1 case, and fever in 1 case. One case was in stage Ⅰ, 7 cases were in stageⅡ, and 3 cases were in stage Ⅳ, and the most common sites of involvement were femur and tibia. All 11 cases were treated with chemotherapy according to different pathological types, with a median follow-up time of 45 months (7-80 months). Ten cases got complete remission, 1 case of BLL died of bone marrow recurrence after chemotherapy remission.Conclusions:The clinical manifestations of primary bone lymphoma in children are insidious, DLBCL is the most common pathological type, and the prognosis is good after standardized treatment.
