Childhood acute lymphoblastic leukemia complicated with cytokine release syndrome: report of 1 case and review of the literature
10.3760/cma.j.cn115356-20220318-00077
- VernacularTitle:儿童急性淋巴细胞白血病合并细胞因子释放综合征1例并文献复习
- Author:
Xiaohui ZHOU
1
;
Shilin LIU
;
Huirong MAI
;
Ying XIN
;
Xue TANG
;
Sixi LIU
;
Ying WANG
Author Information
1. 深圳市儿童医院血液肿瘤科，深圳 518000
- Keywords:
Leukemia, lymphocytic, acute;
Antineoplastic combined chemotherapy protocols;
Cytokine release syndrome;
Glucocorticoids
- From:
Journal of Leukemia & Lymphoma
2022;31(12):730-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the early identification, diagnosis and pathogenesis of childhood acute lymphoblastic leukemia (ALL) complicated with cytokine release syndrome(CRS).Methods:The clinical data of childhood ALL complicated with CRS admitted to Shenzhen Children's Hospital in February 2021 were retrospectively analyzed. The relevant literature was reviewed.Results:The little girl was 2 months and 11 days of age and was diagnosed with ALL with MLL rearrangement positive by bone marrow aspiration because of abdominal mass and abnormal hemogram. She had recurrent high fever with pulmonary imaging characteristic changes during the early intensive induction chemotherapy, accompanied by the elevated interlukin (IL)-2, IL-6, IL-10 and interferon (IFN)-γ. Finally, she was diagnosed with ALL complicated with CRS. Glucocorticoid therapy showed a good efficacy and her clinical symptoms improved.Conclusions:ALL complicated with CRS is essentially induced by cytarabine syndrome drugs in the chemotherapy. The main clinical manifestations include recurrent high fever accompanied by the elevated IL-2, IL-6, IL-10 and IFN-γ. The symptomatic and supportive therapy is usually based on glucocorticoids. Early identification and diagnosis can reduce adverse drug reactions and improve the life quality of children.
