Preliminary estimation of lung cancer risk of radon exposure in a uranium mine using different corrections
10.20001/j.issn.2095-2619.20230217
- VernacularTitle:使用不同修正时某铀矿矿工氡致肺癌超额相对危险系数估算
- Author:
Yanna ZHANG
1
;
Xiaoyan WU
;
Xiangming XUE
;
Xiaona GU
;
Jie HAO
;
Jingming ZHAN
Author Information
1. China Institute of Radiation Protection, Taiyuan, Shanxi 030006, China
- Publication Type:Journal Article
- Keywords:
Radon;
Lung cancer;
Excess relative risk;
Coefficient;
Uranium miner;
Estimate
- From:
China Occupational Medicine
2023;50(1):99-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the correction factors of lung cancer caused by radon exposure in a uranium mine, and estimate the excess relative risk (ERR) coefficient of lung cancer caused by radon in the uranium miners. Methods: Male miners who worked in a uranium mine more than one year in Hunan Province from 1958 to 2018 were selected. This study preliminarily estimated the ERR coefficient of lung cancer caused by radon in the miners with different corrections using the Possion regression model. Results: This study cohort included 4 851 uranium miners, with 187 miners died with lung cancer from 1958 to 2018, and cumulative follow-up of 207 251 person-year. The ERR coefficient of lung cancer caused by radon without correction factors was estimated to be 0.21%/WLM (95%CI: 0.04%/WLM-0.27%/WLM). In the final model, the exponential correction factors of radon-induced lung cancer were time since exposure and exposure rate. In this model, if time since exposure was 45 years and the average exposure rate was 0.14 WL, the estimated ERR coefficient was 1.73%/WLM (95%CI: 0.36%/WLM-3.11%/WLM). The ERR decreases by about 60.00% for every 10 years since exposure, and increases by about 30.00% for every one WL increase exposure rate. Conclusion: The correction factors of lung cancer caused by radon in uranium miners in this mine were the time since exposure and exposure rate. It was preliminarily estimated that the ERR coefficient of lung cancer caused by radon in the occupational radon exposed population in this uranium mine was 1.73%/WLM (95%CI: 0.36%/WLM-3.11%/WLM).
