Simultaneous determination of 18 common disinfection by-product residues in drinking water by high performance liquid chromatography-tandem mass spectrometry
10.19428/j.cnki.sjpm.2023.22731
- VernacularTitle:高效液相色谱-串联质谱法同步测定饮用水中18种常见消毒副产物的方法研究
- Author:
Xiao NING
1
;
Shaoming JIN
1
;
Wenwen SUN
2
;
Jin CAO
1
;
Yusheng PEI
1
Author Information
1. National Institutes for Food and Drug Control，Beijing 100050，China
2. SCIEX China，Beijing 100015， China
- Publication Type:Journal Article
- Keywords:
ultra high performance liquid chromatography-tandem mass spectrometry;
drinking water;
disinfection by-product;
haloacetic acid;
oxyhalide
- From:
Shanghai Journal of Preventive Medicine
2023;35(7):711-718
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveA method was developed for the rapid determination of 18 common disinfection by-products including halogenated oxides and haloacetic acid （HAAs） in drinking water by high performance liquid chromatography tandem mass spectrometry （HPLC-MS/MS）. MethodThe water sample was filtered by 0.22 μm hydrophilic membrane then the analytes were separated on a PFP （2.1 mm× 100 mm， 2.7 μm） pentafluorophenyl column with 0.1% acetic acid and acetonitrile as mobile phase gradient elution. Ionization in anionic electrospray mode was detected by multi-reaction monitoring （MRM） mode. The external standard method was used for quantitation. ResultsThe correlation coefficients of 18 disinfection by-products were above 0.999 in the corresponding linear range. The average spiked recoveries of 1， 10 and20 times of LOQ of each analyte were 91.6%‒101.8%， and the relative standard deviation （RSD） was 1.2%‒6.4%. The LOD and LOQ were 0.020‒2 μg·L-1 and 0.050‒5 μg·L-1， respectively. ConclusionThis method is simple， sensitive and accurate， and could be used for the routine analysis of 18 common disinfection by-products in drinking water.
