Effect of paliperidone palmitate treatment on disease family burden and rehabilitation effect in community schizophrenic patients
10.19428/j.cnki.sjpm.2023.22729
- VernacularTitle:棕榈酸帕利哌酮注射液治疗社区精神分裂症患者的效果分析
- Author:
Xiaolei GE
1
;
Weibo ZHANG
1
;
Chunmei CHEN
1
;
Siyuan HE
1
;
Miaomiao ZHAO
1
;
Jin JIN
1
;
Bin XIE
1
;
Jun CAI
1
;
Yi ZHU
1
Author Information
1. Shanghai Mental Health Center， Shanghai Jiao Tong University School of Medicine， Shanghai 200030， China
- Publication Type:Journal Article
- Keywords:
schizophrenia;
paliperidone palmitate injection;
community;
disease family burden;
rehabilitation
- From:
Shanghai Journal of Preventive Medicine
2023;35(7):684-688
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effect of paliperidone palmitate treatment on schizophrenic patients in the community. Methods446 schizophrenic patients who used paliperidone palmitate injection were selected in Shanghai. Before and after the treatment， the disease family burden scale， the concise evaluation scale of drug treatment compliance， the VAS100 score of treatment satisfaction， the short form of quality of life measurement scale， and the screening scale of social function defects were used to evaluate the effects of paliperidone palmitate injection. The data were statistically analyzed using SPSS 26.0 software. ResultsAfter using paliperidone palmitate injection， the total score of family burden （13.94±12.17）， the score of daily family activities （3.26±2.74）， the score of family entertainment activities （2.21±2.30）， and the score of family relationship （2.79±2.76） were significantly higher than those before the treatment （14.98±12.64， 3.51±2.88， 2.48±2.38， 3.11±2.87， respectively， all with P<0.05）. The scores of the World Health Organization on quality of life brief scale （62.89±11.94） and the medication compliance scale （28.11±5.64） were better than those before treatment （60.67±12.62 and 27.37±6.96， all with P<0.05）. Compared with the prior treatment without paliperidone palmitate injection， the number of readmissions after treatment was significantly reduced （P<0.01）. ConclusionThe treatment of paliperidone palmitate injection has significant effect， which can effectively reduce the disease family burden of Schizophrenic patients， improve their quality of life， enhance their drug compliance， reduce the readmission rate of patients， ensure long-term treatment effect and promote disease recovery.
