Research progress on analgesic effect and adverse drug reactions of opioid receptor agonist-antagonists
- VernacularTitle:阿片受体激动-拮抗剂的镇痛作用及不良反应研究进展
- Author:
Zequan CHEN
1
;
Guowei XIAO
1
;
Jian AO
1
;
Weiwei JIANG
2
Author Information
1. Dept. of Orthopaedics，Wushan County Hospital of Traditional Chinese Medicine，Chongqing 404700，China
2. Dept. of Pharmacy，the Second Affiliated Hospital of Chongqing Medical University，Chongqing 400010，China
- Publication Type:Journal Article
- Keywords:
opioid receptor agonists-antagonists;
endogenous opioid receptors;
analgesia;
adverse drug reactions
- From:
China Pharmacy
2023;34(18):2299-2304
- CountryChina
- Language:Chinese
-
Abstract:
Opioid receptor agonist-antagonists are a class of drugs which have both agonistic and antagonistic effects on opioid receptors. These drugs already on the market mainly include pentazocine， butorphanol， nalbuphine， buprenorphine， dezocine and so on. Compared with pure opioid receptor agonists such as morphine and fentanyl， these drugs have strong analgesic effects， less addictive， and less side effects such as cough， itching and respiratory depression. Due to the different tendentious effects of opioid receptor agonists-antagonists among different endogenous opioid receptors （μ， κ， δ， etc.）， different receptors of subtypes can exhibit different or even opposite effects in terms of affecting emotions and drug dependence. Therefore， the rational use of these drugs can effectively reduce the occurrence of adverse reactions and drug abuse caused by opioid drugs. With the deepening of research on various endogenous opioid receptor subtypes and related drugs in the academic community， opioid receptor agonists- antagonists have broad application space and prospects in improving adverse reactions to opioid drugs and enhancing patient drug compliance.
