Research progress of anti-tumor effect and mechanism of CDDO and its derivatives
- VernacularTitle:CDDO及其衍生物抗肿瘤作用及机制的研究进展
- Author:
Mengying WANG
1
;
Xinyu ZHANG
1
;
Pan DU
1
;
Liyan CHEN
1
Author Information
1. Tumor Research Center of Yanbian University Medical College，Jilin Yanji 133002，China
- Publication Type:Journal Article
- Keywords:
2-cyano-3，12-dioxooleana-1，9（ 11）-dien-28-oic acid;
derivatives;
anti-tumor activity;
mechanism of action
- From:
China Pharmacy
2023;34(18):2287-2292
- CountryChina
- Language:Chinese
-
Abstract:
2-cyano-3，12-dioxooleana-1，9 （11）-dien-28-oic acid （CDDO） is a compound synthesized by taking oleanolic acid， a natural triterpene， as a precursor or precursor， and transforming three modifiable functional groups in the molecule through a series of chemical structure modification. In order to improve its anti-tumor activity， CDDO derivatives are further synthesized. In this paper， the research results of anti-tumor effects and mechanisms of CDDO and its derivatives in recent years are summarized. It is found that CDDO and its derivatives have a wide range of anti-tumor effects， and can show significant anti-tumor effects on breast cancer， pancreatic cancer， lung cancer and ovarian cancer at low concentrations such as micromole or even nanomole， among which CDDO methyl ester compound （CDDO-Me） and CDDO imidazolidinone compound （CDDO-Im） have the most obvious effects. CDDO and its derivatives exert anti-tumor activity mainly by inducing tumor cell apoptosis， and regulating metabolic reprogramming and immune microenvironment. The involved pathways mainly include Janus protein tyrosine kinase （JAK）/ signal transduction and transcription activation protein 3（STAT3） signal pathway， nuclear factor E2-related factor 2 （NRF2） signal pathway， phosphatidylinositol 3 kinase （PI3K）/protein kinase B （also known as Akt）/mammalian rapamycin target protein （mTOR） signal pathway， Wnt/β-catenin signal pathway， nuclear factor κB signal pathway.
