Effects of Yiru tiaojing granules on the pharmacokinetics of olanzapine in rats
- VernacularTitle:抑乳调经颗粒对奥氮平在大鼠体内药动学的影响
- Author:
Huihui ZHENG
1
;
Longyue ZHOU
1
;
Boxin ZHAO
1
;
Chunxia WANG
1
Author Information
1. Dept. of Pharmacy，Nanfang Hospital of Southern Medical University，Guangzhou 510080，China
- Publication Type:Journal Article
- Keywords:
Yiru tiaojing granules;
olanzapine;
pharmacokinetics;
rats
- From:
China Pharmacy
2023;34(18):2182-2186
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effects of Yiru tiaojing granules on the pharmacokinetics of olanzapine in rats. METHODS SD rats were randomly divided into 4 groups according to single-dose administration and multiple-dose administration， with 6 rats in each group. Groups A and B were given olanzapine （5 mg/kg） or olanzapine （5 mg/kg）+Yiru tiaojing granules （0.972 g/kg） in a single gavage， and groups C and D were administered with the same method once a day for 14 d. Blood was collected from the orbital venous plexus before administration and 5， 15， 30 min and 1， 2， 3， 6， 8， 12， 24 h after the last administration， respectively. The blood concentration was determined by LC-MS， and the pharmacokinetic parameters were calculated by using DAS 2.0 software. RESULTS Compared with group A， group B showed a significant decrease in AUC0－24 h， AUC0－∞ and cmax （P＜0.05）， and a significant prolongation of MRT0－24 h， MRT0－∞ and CLz/F （P＜0.05）； there was no statistically significant difference in the pharmacokinetic parameters between group C and group D （P＞0.05）. CONCLUSIONS A single administration of Yiru tiaojing granules can inhibit the absorption of olanzapine in rats， and long-term administration of Yiru tiaojing granules does not have a significant effect on the pharmacokinetic process of olanzapine.
