Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung Cancer
10.3971/j.issn.1000-8578.2023.23.0018
- VernacularTitle:铁死亡在晚期非小细胞肺癌免疫耐药中的研究进展
- Author:
Qianqian ZHAO
1
;
Zhi SUN
;
Yuemei PAN
;
Xuexue HU
;
Chuanxi WANG
Author Information
1. Department of Radiation Oncology, The Provincial Hospital of Shandong First Medical University, Jinan 250021, China
- Publication Type:Research Article
- Keywords:
Ferroptosis;
Advanced Non-small cell lung cancer;
Immunotherapy;
Immunoresistance;
Nanomaterials
- From:
Cancer Research on Prevention and Treatment
2023;50(9):902-907
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel regulatory cell death characterized by iron dependence and mainly caused by the accumulation of lipid peroxides and reactive oxygen species in the cell. This process plays an important role in the development of many malignancies, and has been extensively studied in lung cancer, especially in antitumor therapy. In recent years, the role of ferroptosis in tumor immunotherapy has been gradually explored. Studies showed that targeting ferroptosis can improve the therapeutic efficacy of antitumor immunotherapy. In addition, immunotherapy and ferroptosis can work synergistically to enhance the effectiveness of antitumor therapy, suggesting a potential relationship between ferroptosis and immunotherapy and the possible reversal of immune drug resistance. This study aims to elucidate the characteristics of ferroptosis, and the role and potential clinical applications of ferroptosis in the antitumor immunotherapy of advanced non-small cell lung cancer. We also explore the role of some nanomaterials that target the onset of tumor ferroptosis in facilitating immunotherapy.
