Difference in Intestinal Flora Among Patients with Esophageal Squamous Cell Carcinoma and Normal Population
10.3971/j.issn.1000-8578.2023.23.0297
- VernacularTitle:食管鳞状细胞癌患者与健康人群肠道菌群的差异研究
- Author:
Yanzhen CAO
1
;
Jiajie HU
;
Lili YANG
;
Xinzhi FANG
Author Information
1. Department of Pathology, The Third Clinical Medical College/Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, China
- Collective Name:TUSUNAYI·Wumaier
- Publication Type:Research Article
- Keywords:
Esophageal squamous cell carcinoma;
Intestinal flora;
Markers
- From:
Cancer Research on Prevention and Treatment
2023;50(9):873-878
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference in intestinal flora among patients with esophageal squamous cell carcinoma and normal population and to provide a basis for the early diagnosis of esophageal squamous cell carcinoma as a marker. Methods DNA was extracted from biopsy tissue samples of 30 patients with esophageal squamous cell carcinoma (observation group) and 25 healthy people (control group) by microbial amplification sequencing. The integrity and quality of DNA were detected. The composition and abundance of intestinal flora in the samples of the two groups were determined. Results A great similarity in beta diversity was found between the two groups, but some differences were also observed. The relative abundance of Proteobacteria and Verrucomicrobia in the observation group was higher than that in the control group (P<0.05). The relative abundance of Megamonas in the observation group was lower than that in the control group (P=0.025). Conclusion Strengthening the study on the changes in intestinal flora among patients with esophageal squamous cell carcinoma may be of great significance for its prevention and treatment.
