Voltage Dependent Anion Channel 1 Mediated Inflammation and Obstructive Sleep Apnea Syndrome
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0503
- VernacularTitle:电压依赖性阴离子通道1介导的炎症与睡眠呼吸暂停综合征
- Author:
Chun-fei LIU
1
;
Ping XU
1
Author Information
1. Department of Neurology， Affiliated Hospital of Zunyi Medical University， Zunyi 563000， China
- Publication Type:Review
- Keywords:
VDAC1;
mitophagy;
obstructive sleep apnea syndrome;
inflammasome;
cognitive dysfunction
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(5):735-740
- CountryChina
- Language:Chinese
-
Abstract:
VDAC1（voltage dependent anion channel 1）is an important channel protein on the outer mitochondrial outer membrane， which regulates mitophagy， participates in the regulation of inflammatory cytokines and the activation of the inflammasome， hence being crucial to the inflammatory response. Patients with obstructive sleep apnea syndrome （OSAS） suffer neuroinflammation due to intermittent hypoxia and increased oxidative stress， leading to chronic damage and neuronal cell apoptosis， and eventually develop cognitive impairment. Since OSAS patients' cognitive impairment is significantly influenced by inflammation， and VDAC1 regulates the activation of the inflammasome， the relationship between OSAS and VDAC1， mitophagy， as well as inflammation are reviewed here. We hope that this study can provide a new breakthrough in mitophagy and inflammation in patients with cognitive dysfunction caused by OSAS.
