Laboratory Monitoring of Non-Vitamin K Antagonist Oral Anticoagulants and Their Use in Special Populations
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0502
- VernacularTitle:非维生素K 拮抗剂口服抗凝药实验室监测及特殊人群使用
- Author:
Hua-bo YING
1
;
Xiao HUANG
1
Author Information
1. Department of Cardiology， The Second Affiliated Hospital of Nanchang University， Nanchang 330006， China
- Publication Type:Review
- Keywords:
non-vitamin K antagonist oral anticoagulants （NOACs）;
laboratory monitoring;
thromboembolism;
clinical application
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(5):728-734
- CountryChina
- Language:Chinese
-
Abstract:
In the past few decades， heparin and warfarin have been the main anticoagulants used to treat and prevent venous thromboembolism. Recent studies at home and abroad have shown that non-vitamin K antagonist oral anticoagulants （NOACs） have similar or better efficacy and safety in the prevention and treatment of venous thromboembolism and non-valvular atrial fibrillation. NOACs do not require routine coagulation monitoring when used at a fixed dose. However， in special populations or specific scenarios such as emergency surgery， etc.， an overdose or underdose and abnormal metabolism of NOACs may reduce the drug efficacy and safety， so monitoring and evaluating the anticoagulant effect of NOACs is more conducive to the prognosis of patients.This paper briefly reviewed the common laboratory monitoring methods of NOACs and their use in special populations， aiming to explain different monitoring methods for different NOACs and the applicability of NOACs in special populations， and hoping to provide reference for clinical standard monitoring and use of NOACS.
