Prevalence and Susceptibility of Staphylococcus aureus Nasal Carriage Strains Isolated from Haemodialysis Patients
https://doi.org/10.47836/mjmhs.19.1.25
- Author:
Khairunnisa Mohd Sukri
1
;
Nurul Azmawati Mohamed
1
;
Ilina Isahak
1
;
Abdul Aziz Marwan
2
Author Information
1. Department of Basic Medical Sciences 2, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Persiaran Ilmu, 71800, Nilai, Negeri Sembilan, Malaysia
2. Department of Medical - Based, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Persiaran Ilmu, 71800, Nilai, Negeri Sembilan, Malaysia
- Publication Type:Journal Article
- Keywords:
Antimicrobial susceptibility, Haemodialysis (HD), Methicillin-resistance Staphylococcus aureus (MRSA);
Nasal carriage, Staphylococcus aureus
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.1):181-187
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Staphylococcus aureus is part of the normal human flora that can commonly be found on the skin and
mucous membranes of the nasal area. However, in immunosuppressed patients such as those with kidney failures,
colonization can potentially lead to infection. There is a concern of increasing antibiotic resistance in S. aureus. This
study aimed to determine the prevalence of S. aureus nasal colonization and its antimicrobial susceptibility among
haemodialysis-dependent populations. Methods: A cross-sectional study at the Nephrology Unit, Hospital Canselori Tuanku Mukhriz (HCTM) was conducted among haemodialysis-dependent patients between February 2017 to
February 2018. Nasal swabs were obtained and cultured on mannitol salt agar. S. aureus isolates were identified by
gram staining, tube coagulase and Deoxyribonuclease (DNase). Cefoxitin disc (30 µg) were used to identified the
presence of MRSA (methicillin-resistance S. aureus). The S. aureus colonies were further tested against six antibiotics
using Kirby Bauer disc diffusion. Result: A total of 134 patients were recruited. S. aureus isolates were detected from
27 patients (20.1%). All S. aureus were phenotypically identified as methicillin-sensitive S. aureus (MSSA) based on
the cefoxitin disc. Teicoplanin and linezolid were the most effective with 100% susceptibility. S. aureus exhibited
a high resistance rate towards erythromycin (29.6%). No MRSA was isolated in this study. Conclusion: This study
highlighted the high prevalence of S. aureus nasal colonization in haemodialysis patients. Teicoplanin and linezolid
were found to be the most effective antibiotics against isolated S. aureus.
- Full text:11.2023my1425.pdf
