Association of New Generation Anti-CCP Antibodies with Disease Severity and Functional Status in Rheumatoid Arthritis Patients
https://doi.org/10.47836/mjmhs.19.1.14
- Author:
Maryam Syahidah Azalan
1
;
Wan Majdiah Wan Mohamad
1
;
Norkhafizah Saddki
1
;
Wan Syamimee Wan Ghazali
2
Author Information
1. School of Dental Sciences, Universiti Sains Malaysia Health Campus, 16150 Kubang Kerian, Kelantan
2. Medical Department, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis, anti-CCP antibodies, Disease severity, Functional status
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.1):96-101
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis
(RA) is associated with higher disease activity and lower functional ability. This study investigated the presence of
the new generation of anti-CCP antibodies (anti-CCP2 IgG, anti-CCP2 IgA and anti-CCP3.1 IgG/IgA) and their association with disease severity and functional status of RA patients. Methods: A total of 46 RA patients and 40 healthy
controls participated in this cross-sectional study that was conducted at the Rheumatology Clinic, Hospital Universiti
Sains Malaysia. Blood samples were taken from all participants for anti-CCP2 IgG, anti-CCP2 IgA, and anti-CCP3.1
IgG/IgA analysis. Disease severity and functional status of RA patients were measured using the Disease Activity
Score-28 (DAS28) and the modified Health Assessment Questionnaire (mHAQ) respectively. Results: Significantly higher proportion of RA patients were found with positive anti-CCP2 IgG (63.0%), anti-CCP2 IgA (37.0%), and
anti-CCP3.1 IgG/IgA antibodies (63.0%) than the healthy controls. No significant association was found between
anti-CCP antibodies status and mean DAS28 score of the RA patients. However, RA patients with negative anti-CCP2
IgG status had higher mean mHAQ score than patients with positive anti-CCP2 IgG status. Conclusion: Our study
has demonstrated detection of the new generation anti-CCP antibodies in RA patients, supporting the use of autoantibodies in RA diagnosis. While no significant association was found between the presence of anti-CCP antibodies
and disease severity of RA patients, the absence of anti-CCP2 IgG was associated with worse function and greater
disability of the patients.
- Full text:11.2023my1414.pdf
