Gastrointestinal manifestations and health outcomes in patients with COVID-19 infection in a tertiary hospital
- Author:
Lester Jan Alvarado Olimba
1
;
Ashraf Tawasil
1
;
Adrian Alick Bonghanoy
1
;
Joshua Josef Torres
1
;
Agnes Evasan
2
;
Eric Yasay
1
;
Sonia Salamat
2
;
Francisco N. Delos Reyes
3
Author Information
- Publication Type:Journal Article
- Keywords: Gastrointestinal
- MeSH: Gastrointestinal Tract; COVID-19; Tertiary Care Centers
- From: Journal of the Philippine Medical Association 2022;101(1):84-97
- CountryPhilippines
- Language:English
-
Abstract:
Objectives:To determine the frequencies of
gastrointestinal manifestations and identity associations with outcomes among COVID-19 patients admitted in a tertiary hospital. Furthermore, it sought to determine conditions and risk factors that can be attributed to the development of these gastrointestinal symptoms.
Materials and Methods:This was a retrospective cohort of 1212 adult patients admitted at the Philippine General Hospital from April to September 2020 for COVID-19 infection. Data were gathered from an established database and chart review. Frequencies of observations were tabulated and expressed in percentages. Analytical statistics via the Fisher's Exact test was used to determine associations.
Results:A total of 597 observations of gastrointestinal symptoms was noted: diarrhea (16.4%), anorexia (13.3%), ageusia/dysgeusia/hypogeusia (7.7%), vomiting (4.5%), abdominal discomfort (4.7%), nausea (1.7%), and gastrointestinal bleeding (0.7% - [melena 0.5%, hematochezia 0.16%, hematemesis 0.08%]). Most of these patients had moderate COVID infection (38.37%). Gastrointestinal bleeding was significantly associated with the need for oxygen support (p = 0.009), invasive ventilation (p = 0.002), invasive ventilation (p= 0.001), ICU admission (p = 0.006) and mortality (p= 0.006). Anorexia was significantly associated with the need for oxygen support (p = <0.001), invasive ventilation (p= <0.001), renal replacement therapy (p = 0.003), ICU admission (p = <0.001) and mortality (p = <0.001). Vomiting was significantly associated with need for invasive ventilation (p = 0.023) and renal replacement therapy (p = 0.003).
Conclusion:Gastrointestinal manifestations can present among patients with COVID-19 infection and can affect overall prognosis. - Full text:PMA 1.pdf
