Prophylactic paracetamol for intraoperative shivering prevention for patients undergoing gynecological procedures under spinal anesthesia: A randomized clinical trial
- Author:
Angeline Bonne P. Regadio
1
Author Information
- Publication Type:Journal Article
- Keywords: Shevering; Prophylaxis
- MeSH: Acetaminophen; Anesthesia, Spinal
- From: Journal of the Philippine Medical Association 2022;101(1):68-78
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Shivering is defined as an involuntary, repetitive activity of skeletal muscles. Mechanisms of shivering for patients undergoing surgical operation include intraoperative heat loss, increase sympathetic tone, pain, and systemic release of pyrogens. Regional anesthesia, particularly spinal anesthesia causes redistribution of core heat to the peripheral tissues this in turn predisposes patient to shivering and hypothermia. The median incidence of shivering related to regional anesthesia observed in a review of 21 studies is 55%. Paracetamol is one of the most commonly used analgesic and antipyretic drugs around the world, available without a prescription, it has analgesic and antipyretic property similar to NSAIDs it also affects core body temperature through the hypothalamus.
Though different modalities have been established for shivering prevention, the search for a cost-effective drug with lesser side effects and improvement of patient satisfaction still continues.
Objective:The aim of this study was to evaluate the effect of prophylactic dose of Paracetamol on postanesthesia shivering on patients undergoing, gynecological procedures under spinal anesthesia as compared to patients not given Paracetamol.
Methodology:This is a Double blind, Randomized, Placebo Controlled conducted in patients scheduled for benign gynecological procedures such as Hysterectomy with or without adnexectomy. Using simple random sampling through fishbowl method and a sample size of 42, all patients who consented to participate in the study was randomly assigned to receive Paracetamol 900 mg IV or Placebo 0.9% Saline intravenously 30 minutes prior to induction of spinal anesthesia. Incidence and severity of Shivering was documented using shivering five point scale outlined by Crossley and Mahajan, while patient satisfaction was also evaluated using the Likert Scale, possible side effects was also assessed. - Full text:PMA-Journal-5.pdf
