Gestational trophoblastic neoplasia coexisting with cervical carcinoma: A case report

Author: Agnes L. Soriano‑Estrella ¹ ; Julie Ann B Bolastig‑Canson ¹ ; Ginessa Grace G. Rendaje ¹ ; May Delight G. Galingan ¹
Author Information

1. Division of Trophoblastic Diseases, Department of Obstetrics and Gynecology, Philippine General Hospital, University of the Philippines, Manila, Philippines
Publication Type:Case Reports
Keywords: Human chorionic gonadotrophin
MeSH: Uterine Cervical Neoplasms; Gestational Trophoblastic Disease
From: Philippine Journal of Obstetrics and Gynecology 2023;47(3):142-148
CountryPhilippines
Language:English
Abstract: Gestational trophoblastic neoplasia (GTN) with a concurrent cervical malignancy is very rare, making the case both a diagnostic dilemma and a therapeutic challenge. Currently, there has only been one reported case worldwide. We present a case of GTN Stage I:11 with non‑keratinizing squamous cell carcinoma of the cervix Stage II‑B. Initial treatment, in the form of chemotherapy, was directed toward the GTN, as this appeared to be the more aggressive disease. Surgery was not feasible during diagnosis due to the cervical carcinoma. However, the GTN proved resistant to chemotherapy due to the increasing beta human chorionic gonadotropin titers. An attempt to decrease the size of the cervix for surgery to be possible through chemoradiation was instituted, but due to complications and tumor progression to the lungs, she succumbed to the malignancy.
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