SOLAMEN syndrome in a Filipino child
https://doi.org/10.47895/amp.vi0.4252
- Author:
Ebner Bon G. Maceda
1
;
Mary Ann R. Abacan
2
;
Eva Maria C. Cutiongco-de la Paz
3
Author Information
1. Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila
2. Department of Pediatrics, College of Medicine, University of the Philippines Manila
3. National Institutes of Health, University of the Philippines Manila
- Publication Type:Journal Article
- Keywords:
SOLAMEN Syndrome;
Overgrowth Syndromes;
PTEN gene
- MeSH:
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi
- From:
Acta Medica Philippina
2022;56(17):65-69
- CountryPhilippines
- Language:English
-
Abstract:
Asymmetric overgrowth syndromes are a diverse group of diseases with overlapping features including asymmetric overgrowth of a body part, vascular malformations, lipomatosis, and epidermal nevus. Three important considerations when presented with these features are Proteus syndrome, CLOVES (Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Skeletal anomalies) syndrome and SOLAMEN (Segmental Overgrowth, Lipomatosis, Arteriovenous Malformation, Epidermal Nevus) syndrome. This paper aimed to present a rare case of asymmetric overgrowth syndrome. A 3-year-old child with asymmetric overgrowth of the right upper and lower extremities was seen at the clinic. He also had epidermal nevus, lipomatosis, skeletal abnormalities, and vascular malformation. The history showed the presence of segmental proportionate overgrowth with soft tissue hypertrophy and ballooning effect based specifically on the location, timing, and progression of overgrowth. On physical examination, macrocephaly was also noted. Based on these features, the diagnosis of SOLAMEN syndrome was made. This is the first reported case of SOLAMEN syndrome in the Philippines. The importance of a careful and thorough history and physical examination cannot be overemphasized. A multidisciplinary approach in management with appropriate referral to subspecialists and early monitoring for possible malignancies are needed.
- Full text:4252-Article Text-80974-1-10-20220928.pdf
