Determination of camphor residue and borneol content in Qingchang suppository by GC
10.12206/j.issn.2097-2024.202208110
- VernacularTitle:气相色谱法测定清肠栓中樟脑残留量和冰片含量
- Author:
Yujiong PAN
1
;
Zhigao HE
1
;
Xin ZHOU
1
;
Hengzhou ZHANG
2
;
Yuehong YANG
1
;
Jingshan HUANG
1
Author Information
1. Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032 China.
2. Shanghai Wanshicheng Pharmaceutical limited, Shanghai 201507 China.
- Keywords:
GC;
Qingchang suppository;
camphor;
borneol;
isoborneol;
content determination
- From:
Journal of Pharmaceutical Practice
2023;41(9):552-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a gas chromatography for simultaneous determination of camphor residue and borneolum content in Qingchang Suppository. Methods Gas chromatograph method was used. The chromatographic column was Agilent capillary column(30 m×0.25 mm×0.25 µm). The column temperature was 140 ℃. The sample injection temperature was 250 ℃. The FID detector temperature was 250 ℃. Results Camphor，borneol and isoborneol content showed good linear in the extent of 0.0299~1.497(r=1.000), 0.0205~1.025(r=1.000), 0.0097~0.4830 µg (r=1.000). RSDs of precision，stability and repeatability test results were less than 2%. The recovery was 99.7%, 101.0%, 102.5%. Conclusion This method is simple and quick with accurate result, which could be used for the content determination of Borneol in Qingchang Suppository.
