Research progress on linear ubiquitin chain assembly complex and OTU deubiquitinase with linear linkage specificity in tumor
10.12206/j.issn.2097-2024.202307045
- VernacularTitle:线性泛素连接酶复合体与去线性泛素化酶在肿瘤中的研究进展
- Author:
Yuxin FANG
1
;
Yu LI
1
;
Baoshu LIU
1
;
Guoqiang DONG
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
linear ubiquitination;
linear ubiquitin chain assembly complex;
OTU deubiquitinase with linear linkage specificity;
tumor
- From:
Journal of Pharmaceutical Practice
2023;41(9):534-539
- CountryChina
- Language:Chinese
-
Abstract:
Linear ubiquitination is an important post-translational modification that has been discovered in recent years. The linear ubiquitin chain is formed by the linkage of glycine residue of one ubiquitin protein to the methionine residue of another ubiquitin. This process is regulated by the linear ubiquitin chain assembly complex (LUBAC) and the OTU deubiquitinase with linear linkage specificity (OTULIN). Linear ubiquitination is involved in various biological processes, including immune response, inflammation, and cell apoptosis. Recent studies have shown that linear ubiquitination is closely related to the occurrence, development, and drug resistance of tumors by affecting signaling pathways such as NF-κB and Wnt/β-catenin. The research progress on the function of LUBAC and OTULIN in tumors was reviewed in this paper.
