Green synthesis of gold nanoparticles from Sophora flavescens extract and their antibacterial effect against some pathogenic bacteria
- Author:
Marwah Thamir Abdulsattar Alnuaimi
1
;
Huda S. A. AL-Hayanni
2
;
Zahraa Zahraw Aljanabi
3
Author Information
- Publication Type:Journal Article
- Keywords: Antibacterial activity; Gold nanoparticles; Green synthesis; Multi-drug resistance pathogenic bacteria; Sophora flavescens
- MeSH: Anti-Bacterial Agents; Sophora flavescens
- From:Malaysian Journal of Microbiology 2023;19(1):74-82
- CountryMalaysia
- Language:English
-
Abstract:
Aims:The current study was aimed to evaluate the antibacterial activity of biogenic synthesized golden nanoparticles from Sophora flavescens Aiton roots aqueous extract against multidrug-resistant (MDR) clinical bacterial isolates.
Methodology and results:The green synthesis of gold nanoparticles (AuNPs) was accomplished using S. flavescens roots aqueous extract and examined using many accepted techniques. The antibacterial activity of S. flavescens extract and the aqueous AuNPs at concentrations (7% and 9%) ppm were investigated against two clinical MDR bacteria, including Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa). The findings demonstrate inhibitory activity against the selected MDR bacterial isolates for the aqueous extract of S. flavescens and the aqueous AuNPs noted by the significant decrease in the number of bacteria after treatment with highly significant differences (P≤0.01) compared to the untreated control.
Conclusion, significance and impact of study:Sophora flavescens root extracts and their biosynthesized AuNPs with antibacterial activity may find broad applications in fighting MDR pathogenic bacteria and therapeutic manufacturing. - Full text:20.2023my0009.pdf
