Significance and Prospect of Tryptophan Metabolism in Treatment of Tumor Immune Checkpoint Inhibitors
10.3971/j.issn.1000-8578.2021.20.1238
- VernacularTitle:色氨酸代谢在肿瘤免疫检查点抑制剂治疗中的意义及前景
- Author:
Yamei GAO
1
;
Bin WANG
;
Zhongxin LI
;
Yitao JIA
Author Information
1. Graduate School of Hebei Medical University, Shijiazhuang 050000, China
- Publication Type:Research Article
- Keywords:
Tryptophan metabolism;
Kynurenine;
5-hydroxytryptamine;
Indole;
Immune checkpoint
- From:
Cancer Research on Prevention and Treatment
2021;48(5):541-546
- CountryChina
- Language:Chinese
-
Abstract:
Although immune checkpoint inhibitors (ICIs) have great breakthrough in cancer treatment in recent years, most patients have not benefited from it on account of immune microenvironment. Studies have shown that tryptophan metabolism is not only involved in the formation of tumor immunosuppressive microenvironment but also plays an important role in the therapeutic application of ICIs. At present, inhibiting the kynurenine pathway of tryptophan metabolism is now in various stages of clinical trials, while the other two metabolic pathways, 5-HT and the indole pathway, also have aroused wide concern. This article reviews the latest developments in this field.
