Relation Between CD8+T Lymphocyte Infiltration and Efficacy of Neoadjuvant Chemotherapy for Triple-negative Breast Cancer
10.3971/j.issn.1000-8578.2021.20.1191
- VernacularTitle:CD8+T淋巴细胞浸润与三阴性乳腺癌新辅助化疗疗效的关系
- Author:
Tiandong KONG
1
;
Lu CHEN
;
Fangfang DUAN
;
Liuyan WANG
;
Hanli ZHOU
;
Xiaoli ZHAO
;
Mengmeng LIU
;
Danna LIU
Author Information
1. Breast Oncology Department, Cancer Hospital of Henan University (The Third People's Hospital of Zhengzhou), Zhengzhou 450000, China
- Publication Type:Research Article
- Keywords:
Triple-negative breast cancer;
CD8+T lymphocyte infiltration;
Neoadjuvant chemotherapy
- From:
Cancer Research on Prevention and Treatment
2021;48(5):484-488
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between the characteristics of CD8+T lymphocyte infiltration and the prognosis of triple-negative breast cancer patients. Methods We retrospectively analyzed the clinicopathological data of 126 patients with triple-negative breast cancer undergoing preoperative neoadjuvant chemotherapy. Immunohistochemical staining was used to analyze the relation between CD8+T lymphocyte infiltration and clinicopathological characteristics. Kaplan-Meier method was used to draw the survival curve, and Cox risk ratio regression model was used to analyze the prognostic factors affecting disease-free survival time (DFS). Results High-density CD8+Tils was associated with age < 60 years old, high pathological grade and high clinical stage (P < 0.05). The pCR rate of high-density CD8+Tils group was higher than that of the low-density group (66.7% vs. 19.8%, P=0.000). The median DFS of the high-density group was significantly longer than that of the low-density group (49 vs. 25 months, P < 0.05). Multivariate analysis showed that high pathological grade, tumor diameter > 2 cm, lymph node metastasis, vascular invasion and CD8+Tils low-density infiltration were factors for poor prognosis (P < 0.05), and CD8+Tils was an independent prognostic factor. Conclusion CD8+Tils may be an independent prognostic indicator for triple-negative breast cancer. The patients with high-density infiltration have high postoperative pCR rate, long DFS and better long-term efficacy.
