Dosimetric Analysis of Template-assisted <sup>192</sup>Ir-source Hypofractionated Stereotactic Ablative Brachytherapy for Peripheral Lung Cancer

VernacularTitle:模板辅助¹⁹²Ir源大分割立体近距离放射消融术治疗周围型肺癌的剂量学研究
Author: Qin GAO ¹ ; Haowen PANG ; Xiangxiang SHI ; Peirong REN ; Sheng LIN
Author Information

1. Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
Publication Type:Research Article
Keywords: Stereotactic ablative brachytherapy; ¹⁹²Ir-source; Peripheral lung cancer; Stereotactic body radiation therapy
From: Cancer Research on Prevention and Treatment 2021;48(5):474-478
CountryChina
Language:Chinese
Abstract: Objective To explore the dose of template-assisted ¹⁹²Ir source hypofractionated stereotactic brachytherapy (SABT) for peripheral lung cancer. Methods We retrospectively analyzed the dose parameters of GTV and OARs of 28 peripheral lung cancer patients treated with template-assisted ¹⁹²Ir-source hypofractionated SABT, and compared the dose parameters between SABT with virtual SBRT. Results The D_mean and V₁₅₀ for the GTV in the SABT plan were significantly higher than those in the SBRT plan (all P < 0.01). For OARs, all dosimetric parameters in the SABT plan were significantly lower than those in the SBRT plan (all P < 0.01), except for the D_1000cm³ and D_1500cm³ for the lung (P > 0.05). Conclusion Template-assisted ¹⁹²Ir source hypofractionated SABT ensures high dose in the gross tumor volume and reduces the dose in organs at risk in the treatment of peripheral lung cancer.