Association Between Osteogenic Differentiation in Soft Tissue Lump and Clinicopathological Characteristics of Osteosarcoma Patients
10.3971/j.issn.1000-8578.2021.21.0082
- VernacularTitle:骨肉瘤软组织肿块骨化程度与患者临床病理特征的相关性
- Author:
Zhaoyang WU
1
;
Shenglin WANG
;
Rongkai SHEN
;
Fei CHEN
;
Jianhua LIN
;
Xia ZHU
;
Zhenzhen ZHANG
Author Information
1. Department of Orthopaedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
- Publication Type:Research Article
- Keywords:
Osteosarcoma;
Osteogenesis;
Chemotherapy;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2021;48(9):859-863
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the osteogenic differentiation in the soft tissue lump and the clinicopathological characteristics of osteosarcoma patients. Methods We retrospectively reviewed the clinical data of conventional osteosarcoma patients with soft tissue lumps, including Enneking stages, chemotherapy sensitivity, overall survival and post-metastatic survival time. The ossification level in soft tissue lumps was assessed by imaging and the proportion of osteoid matrix was assessed by pathological examination. Results A total of 189 cases were included in this study. In patients with Enneking IIIB, non-osteoblastic, partially osteoblastic and osteoblastic types accounted for 30.2%, 9.6% and 6.3%, respectively. Non-osteoblastic osteosarcoma patients had a higher rate of initial metastasis (P < 0.05); Chemotherapy efficiency of non-osteoblastic, partially osteoblastic and osteoblastic types were 60.5%, 59.6% and 31.3%, respectively. The osteoblastic osteosarcoma held the worst rate of chemotherapy sensitivity (P < 0.05). The overall survival of non-osteoblastic osteosarcoma was shorter than those of partially osteoblastic and osteoblastic types (P < 0.05). Post-metastatic survival time of osteoblastic osteosarcoma was longer than that of non-osteoblastic osteosarcoma (P=0.078). Conclusion For conventional osteosarcoma, the osteogenesis level in soft tissue lumps is related to the surgical stage, chemotherapy sensitivity and prognosis of tumors, which may provide guidance for the individual decision regarding chemotherapy and surgery timing on patients.
