Research Progress on CircRNA in Liquid Biopsy of Gastric Cancer
10.3971/j.issn.1000-8578.2021.21.0517
- VernacularTitle:CircRNA在胃癌液体活检中的研究进展
- Author:
Hao ZHU
1
;
Jianchao JIA
;
Lan YU
Author Information
1. Graduate School of Inner Mongolia Medical University, Hohhot 010000, China
- Publication Type:Research Article
- Keywords:
CircRNA;
Liquid biopsy;
Exosome;
Gastric cancer
- From:
Cancer Research on Prevention and Treatment
2021;48(11):1023-1029
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer has become a major public health problem in China because of its high prevalence. CircRNA could stably exist in various human body fluids, providing the innate advantage for the liquid biopsy, which makes it a research hotspot in the field of precision therapy in recent years. Based on the biological characteristics of circRNAs, we summarize the research progress of circRNAs in the early diagnosis, treatment monitoring and prognosis assessment of gastric cancer through literature retrieval in mainstream databases such as PubMed, Web of Science and CNKI. We also discuss the possibility and reliability of circRNA as an emerging liquid biopsy biomarker, to offer a vision for the development and clinical transformation of circRNA as a molecular marker of the diagnosis, treatment, evaluation and prognosis of gastric cancer in the future.
