CircRNA hsa_circ_0044569 as A Potential Biomarker for Diagnosis of Lung Cancer
10.3971/j.issn.1000-8578.2021.21.0488
- VernacularTitle:CircRNA hsa_circ_0044569在肺癌诊断中的价值
- Author:
Yanjun HOU
1
;
Jinhai TIAN
;
Libin WANG
;
Jinxi HE
Author Information
1. Department of General Thoracic Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
- Publication Type:Research Article
- Keywords:
circRNA;
Biomarker;
Lung cancer
- From:
Cancer Research on Prevention and Treatment
2021;48(12):1061-1065
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen out the biomarkers with diagnostic value in lung cancer by biochip technology. Methods We screened four pairs of differentially-expressed circRNAs in lung cancer by circRNA expression profiling chip, and then verified the screened differential circRNA hsa_circ_0044569 by qRT-PCR, and collected clinical case information of patients at the same time. The independent sample t test and ROC curve were used to analyze the relation between the clinical data of lung cancer patients and the expression of circRNA hsa_circ_0044569 on clinical samples. Results The expression level of hsa_circ_0044569 in lung cancer tissues was higher than that of its paired adjacent tissues. The cutoff value of hsa_circ_0044569 for the diagnosis of lung cancer was 9.62, AUC was 0.758, P < 0.05, sensitivity was 0.712, and specificity was 0.712. The expression of hsa_circ_0044569 was significantly related with the pathological type of lung cancer patients (P < 0.05). Conclusion hsa_circ_0044569 is highly expressed in lung cancer and related to the pathological type, suggesting that it may become a potential biomarker in the early diagnosis of lung cancer.
