Research Progress of CircRNAs Regulating Biological Behavior of Clear Cell Renal Cell Carcinoma

VernacularTitle:环状核糖核酸调节肾透明细胞癌生物学行为的研究进展
Author: Huijie ZHANG ¹ ; Liting LIU ; Hongwei CUI ; Lei YU ; Genquan YUE
Author Information

1. Clinical Research Center, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
Publication Type:Research Article
Keywords: Cyclic ribonucleic acids; Clear cell renal cell carcinoma; Biological behavior
From: Cancer Research on Prevention and Treatment 2021;48(8):814-819
CountryChina
Language:Chinese
Abstract: Renal cell carcinoma is one of the ten multiple cancers, and its incidence rate and mortality rate have been increasing in more than 20 years. Clear cell renal cell carcinoma (ccRCC) is the most common histopathological subtype. Cyclic ribonucleic acids (circRNAs) are noncoding ribonucleic acids, which are widely distributed with diverse cellular functions and have organ- and tissue-specific expression patterns. Recent studies have shown that circRNAs are abnormally expressed in ccRCC and play an important role in the occurrence and development of ccRCC. However, there are few researches and related mechanisms of circRNAs regulating the biological behavior of ccRCC. Therefore, the paper mainly describes the research progress of circRNAs regulating the biological behavior of ccRCC and discusses its potential as a biomarker for early diagnosis and prognosis of ccRCC and targeted therapy.