Research Progress of Immunoscore in Prediction of Tumor Prognosis and Efficacy to Treatment
10.3971/j.issn.1000-8578.2021.21.0182
- VernacularTitle:免疫评分在肿瘤预后及疗效预测中的研究进展
- Author:
Yuting LI
1
;
Junli DING
;
Huiyu WANG
;
Junying XU
Author Information
1. Department of Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214000, China
- Publication Type:Research Article
- Keywords:
Immunoscore;
Tumor;
Prognosis;
Efficacy prediction
- From:
Cancer Research on Prevention and Treatment
2021;48(8):809-813
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of the tumor are closely associated with the tumor microenvironment (TME) and host immune status. Traditional TNM staging has gradually been insufficient in the assessment of patients' outcomes, as the TNM system solely evaluated tumor cell characteristics and failed to predict clinical outcomes based on immune factors. Therefore, immunoscore (IS), derived from the concept of immune contexture, was proposed to establish a more comprehensive and accurate TNM-I staging above the TNM staging. Recently, increasing studies have shown that IS can predict the survival outcome and treatment efficacy more accurately than TNM staging. Moreover, IS possess characteristics such as feasibility, convenience, robustness and reproducibility, which make it possible for IS to be used as a biomarker for clinical application, to classify patients better and contribute to developing individualized treatment strategies, ultimately, to improve the overall survival of patients with cancer. This article reviews of the progress of immunoscore in predicting patients' prognosis and response to therapy among different tumors.
