Prognosis-related Factors of Colorectal Cancer Patients with Positive PD-L1 Expression in Liver Metastases After Hepatectomy
10.3971/j.issn.1000-8578.2021.21.0124
- VernacularTitle:结直肠癌肝转移灶中PD-L1基因阳性患者肝切除后的预后相关因素
- Author:
Zhengqiang ZHAO
1
;
Long CHEN
;
Yujie LIU
;
Suqing TIAN
Author Information
1. Department of Surgical, Dongfang People's Hospital, Dongfang 572600, China
- Publication Type:Research Article
- Keywords:
Colorectal cancer;
Surgery;
Positive PD-L1 expression;
Liver metastases;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2021;48(8):782-787
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognosis-related factors of colorectal cancer patients with positive PD-L1 expression in liver metastases after hepatectomy. Methods We reviewed retrospectively the clinical data of 68 colorectal cancer patients with positive PD-L1 expression in liver metastases receiving personalized comprehensive treatment which was mainly consisted of surgical resection. We observed the results and prognosis after surgical resection and analyzed related factors. Results Univariate analysis showed that no radiotherapy, N stage, RAS mutation status, T stage, dMMR, Duck stage, disease free interval from primary to metastases≤12 months and largest hepatic tumor diameter > 5 cm had obvious significance (all P < 0.05). Multivariate logistic analysis regression revealed that without dMMR (P=0.012), Duck A stage (P=0.000), disease free interval from primary to metastases > 12 months (P=0.020) and largest hepatic tumor diameter < 5 cm (P=0.006) were independent protective factors for the prognosis of colorectal cancer patients with positive PD-L1 expression in liver metastases after surgical resection. Conclusion Personalized comprehensive treatment which is mainly consisted of surgical resection still has a good effect on colorectal cancer patients with positive PD-L1 expression in liver metastases after hepatectomy. Without dMMR, Duck A stage, disease free interval from primary to metastases > 12 months and largest hepatic tumor diameter ≤5cm are independent protective factors for patients' prognosis.
