Expression and Clinical Significance of miRNA-152 in Hepatocellular Carcinoma
10.3971/j.issn.1000-8578.2021.21.0296
- VernacularTitle:miRNA-152在肝癌组织中的表达及临床意义
- Author:
Qiliu PENG
1
;
Shangmou WEI
;
Lei ZHANG
;
Liying GAN
;
Zhen XIE
;
Qiaopei CHEN
;
Bangning WEI
;
Zhi ZHANG
Author Information
1. Department of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital, Nanning 530201, China
- Publication Type:Research Article
- Keywords:
Hepatocellular carcinoma;
MicroRNA-152;
Overall survival;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2021;48(8):769-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of microRNA-152 in hepatocellular carcinoma, and analyze the correlation of miR-152 expression with the clinicopathological characteristics of hepatocellular carcinoma(HCC) patients. Methods Real-time PCR was used to detect the expression of miR-152 in tissue specimens from HCC and the adjacent non-cancerous hepatic tissues collected from 56 patients who underwent surgical treatment for primary HCC. The association between the expression of miR-152 and the clinical pathological characteristics and prognosis of HCC patients was analyzed. Results The relative expression of miR-152 in hepatocellular carcinoma and corresponding adjacent non-carcinoma tissues were 0.616±0.041 and 0.768±0.042 (P=0.011). The expression of miR-152 was significantly associated with TNM stages (P=0.042), tumor differentiation (P=0.035), metastasis (P=0.048) and venous invasion (P=0.042). There was no significant association between the miR-152 expression and gender, age, AFP level, tumor number or tumor grade. The OS (P=0.035) and PFS (P=0.012) in the low miR-152 expression group were obviously shorter than those in the high miR-152 expression group. Multivariate Cox regression analysis showed that the low expression of miR-152, tumor recurrence and pathological classification were significant independent prognostic factors for the prognosis of hepatocellular carcinoma patients. Conclusion The expression of miR-152 is decreased in hepatocellular carcinoma tissues, and the low expression of miR-152 is significantly associated with TNM stages, tumor differentiation, metastasis, venous invasion and the prognosis of HCC patients.
