Trends of Pancreatic Cancer Incidence and Mortality in Changning District of Shanghai
10.3971/j.issn.1000-8578.2021.20.1116
- VernacularTitle:上海市长宁区胰腺癌发病率和死亡率趋势分析
- Author:
Jie FANG
1
;
Jie WANG
;
Honglan LI
;
Guoshan FENG
;
Hua WU
;
Yufei JIANG
;
Yu JIANG
;
Lei ZHANG
;
Yun ZHANG
;
Peng ZHOU
;
Qinghua XIA
;
Wensui ZHAO
;
Yongbing XIANG
Author Information
1. State Key Laboratory of Oncogenes and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China
- Publication Type:Research Article
- Keywords:
Pancreatic cancer;
Incidence;
Mortality;
Trend analysis;
Age-period-cohort model
- From:
Cancer Research on Prevention and Treatment
2021;48(7):727-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the secular trends of pancreatic cancer incidence and mortality in Changning district of Shanghai from 1974 to 2013. Methods We calculated the age-standardized rates of incidence and mortality and the average annual percent changes for pancreatic cancer using Segi's world standard population and the data from Shanghai Cancer Registry. Age-period-cohort model was constructed to further assess the effect of age, diagnosis period and birth cohort on the secular trends of pancreatic cancer incidence and mortality. Results During 1974-2013, the age-standardized incidence and mortality rates were 6.49/105 and 6.01/105 in male, 4.83/105 and 4.57/105 in female, respectively. The age-standardized incidence was increased by 0.8% per year in male during past 40 years, while there was no change in mortality. The age-standardized incidence and mortality rates were increased by 1.6% and 1.3% per year in female. After adjusting the effects of diagnosis period and birth cohort, the incidence and mortality rates of pancreatic cancer increased by about 11% every 5 years older in both male and female. Diagnosis period and birth cohort had no statistical impact on the incidence and mortality of pancreatic cancer. Conclusion The age-standardized incidence of pancreatic cancer shows significantly rising trends during 1974-2013 in both male and female in Changning district of Shanghai, as well as the age-standardized mortality in female. The incidence and mortality rates also increase with age.
