Clinical Efficacy of Anlotinib Combined with Paclitaxel and Cisplatin as First-line Treatment of Advanced Esophageal Squamous Cell Carcinoma
10.3971/j.issn.1000-8578.2021.21.0095
- VernacularTitle:安罗替尼联合紫杉醇和顺铂一线治疗晚期食管鳞癌的疗效分析
- Author:
Xiaoli YANG
1
;
Cailing WANG
;
Jin XIA
;
Junsheng WANG
Author Information
1. Department of Internal Medicine, Anyang Tumor Hospital, Anyang 455000, China
- Publication Type:Research Article
- Keywords:
Esophageal squamous cell carcinoma;
Anlotinib;
Paclitaxel;
Cisplatin;
Chemotherapy;
Adverse reaction
- From:
Cancer Research on Prevention and Treatment
2021;48(7):719-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and side effects of anlotinib combined with paclitaxel and cisplatin as the first-line treatment of advanced esophageal squamous cell carcinoma (ESCC). Methods We retrospectively analyzed 50 cases of advanced esophageal squamous cell carcinoma diagnosed pathologically. Among them, 24 cases were treated with the combination of anlotinib and paclitaxel plus cisplatin (experimental group), and 26 cases were treated with paclitaxel plus cisplatin regimen (control group). The efficacy and adverse reactions were observed and followed up. Results The objective response rates of the experimental and control groups were 83.33% and 53.84% (P < 0.05), the disease control rates were 100% and 96.15% (P > 0.05), mPFS were 10.6 and 9.13 months (P < 0.05), and mOS were 13.4 and 11.8 months (P < 0.05). The common adverse events in the experimental group were hand-foot syndrome (12.5%), hypertension (12.5%), epistaxis (8.33%) and proteinuria (4.16%), all of which were grade Ⅰ-Ⅱ and controllable without affecting the continuity of chemotherapy. Conclusion The combination of anlotinib, paclitaxel and cisplatin as the first-line treatment of advanced esophageal squamous cell carcinoma can improve the curative effect and the adverse effects are endurable.
