Effect of SABP, A Water-soluble Component of Salvia Miltiorrhiza, on Immune Microenvironment of Mice with Liver Cancer
10.3971/j.issn.1000-8578.2021.20.1405
- VernacularTitle:丹参水溶性组分SABP对小鼠肝癌免疫微环境的影响
- Author:
Shenghao LI
1
;
Liyuan HAO
;
Yinglin GUO
;
Qing PENG
;
Jingru DING
;
Xinli SHI
Author Information
1. Hebei Provincial Key Laboratory of Integrative Medicine for Liver & Kidney Diseases, Shijiazhuang 050091, China
- Publication Type:Research Article
- Keywords:
Salvia miltiorrhiza;
Water-soluble component;
Hepatocellular carcinoma;
Immune microenvironment;
Orthotopic transplantation tumor
- From:
Cancer Research on Prevention and Treatment
2021;48(7):694-698
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of SABP, a water-soluble component of Salvia miltiorrhiza, on the growth of orthotopic transplantation of H22 liver cancer and the immune microenvironment of liver cancer. Methods We established a mouse model of orthotopic transplantation of H22 cell liver cancer in BALB/c mice. ELISA was used to detect the expression of PD-L1, TGF-β, IL-1β, IL-10, IL-4, IFN-γ, IL-18, IL-7, IL-2, CCL-2 and CCL-21 in the liver. We counted the organ indexes of liver, spleen and kidney. Results SABP inhibited the growth of orthotopic transplantation tumors of H22 cell liver cancer, and increased the expression levels of PD-L1, TGF-β, IL-1β and IL-10 in the microenvironment of liver cancer, as well as the liver, spleen and kidney coefficients. Conclusion SABP could inhibit the growth of orthotopic transplantation tumors of H22 cell liver cancer and promote the expression of PD-L1, TGF-β, IL-1β and IL-10 in the microenvironment of liver cancer.
