Recent Advance in Biomarkers for Predicting Immune-related Adverse Events Caused by Immune Checkpoint Inhibitors
10.3971/j.issn.1000-8578.2021.20.0997
- VernacularTitle:免疫检查点抑制剂的免疫相关不良事件预测生物标志物研究进展
- Author:
Ying LI
1
;
Haoyuan YIN
;
Li PAN
;
Lei FENG
Author Information
1. Department of Laboratory, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi 653100, China
- Publication Type:Research Article
- Keywords:
Immune checkpoint inhibitors;
Immune-related adverse events;
Biomarkers
- From:
Cancer Research on Prevention and Treatment
2021;48(4):418-423
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, tumor immunotherapy with immune checkpoint as the target has attracted much attention because of its remarkable efficacy. However, with the application of immune-checkpoint inhibitors (ICIs), more and more immune-related adverse events (irAEs) have been reported. IrAEs impose an additional risk of death on tumor patients treated with ICIs, limiting the widespread use of ICIs. To help patients actively prevent irAEs, biomarkers with the predictive value of irAEs are of great significance. This paper reviews the biomarkers with predictive value for irAEs from the aspects of serology, genetics and microbiology.
