Research Progress of Nano-drug Delivery System Targeting Tumor-associated Macrophage in Cancer Treatment
10.3971/j.issn.1000-8578.2021.20.0724
- VernacularTitle:基于肿瘤相关巨噬细胞为靶点的纳米载药体系在癌症治疗中的研究进展
- Author:
Chenchen WANG
1
;
Chao DU
;
Xueling GUO
;
Xiyue ZHANG
;
Yingze WANG
Author Information
1. College of Biological Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China
- Publication Type:Research Article
- Keywords:
Tumor-associated macrophages;
Nanomedicine;
Macrophage polarization;
Tumor microenvironment
- From:
Cancer Research on Prevention and Treatment
2021;48(3):307-313
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages(TAMs), abundantly infiltrated in the tumor microenvironment, have a significant influence on tumor metastasis, angiogenesis and immune escape. Therefore, TAMs-targeted immunotherapy has become a hot point in the field of cancer treatment. However, most of the conventional TAMs-targeted agents may cause serious adverse effects, such as short retention time, poor drug enrichment and drug-resistance. In order to overcome these shortcomings, nanobiotechnology has attracted considerable attention. More recently, a series of important progress for nanomedicine has been achieved in the area of drug delivery and diagnostic imaging, because of their special physical and chemical properties. Hence, the TAMs-targeted nanomedicine delivery system provides new ideas for tumor immunotherapy. This paper reviews the role of TAMs in tumor microenvironment, the tumor-promoting mechanism, and introduces the research progress of nanomedicine in TAMs polarization, nanodrug delivery, TAMs-targeted imaging and preventing the TAMs recruitment, so as to provide reference for the application of nanotechnology in tumor immunotherapy.
