Reviews on TCM in Reversing Chemotherapy Resistance of Osteosarcoma from ABC Transmembrane Protein
10.3971/j.issn.1000-8578.2021.20.0623
- VernacularTitle:中医药通过调控ABC跨膜转运蛋白逆转骨肉瘤化疗耐药的研究进展
- Author:
Juxian DING
1
;
Xingwen XIE
;
Wei XU
;
Dingpeng LI
;
Ning LI
;
Jiliang SU
;
Bo LIU
;
Jianguo LI
;
Lijun CHAI
Author Information
1. Department of Orthopedics, Affiliated Hospital of Northwest Minzu University, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
Osteosarcoma;
Chemotherapy resistance;
TCM;
ABC transmembrane protein
- From:
Cancer Research on Prevention and Treatment
2021;48(3):303-306
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma (OS) is the most common primary malignant bone tumor in clinic. It has high mortality and disability rate. Effective neoadjuvant chemotherapy combined with limb salvage surgery can improve the 5-year survival rate of OS patients. Drug resistance or low sensitivity of tumor cells is the most common cause of postoperative local recurrence and metastasis. Therefore, the sensitivity of OS cells to chemotherapy drugs is of great value to the prognosis of the patients. In recent years, traditional Chinese medicine has been widely used because of high efficiency and low toxicity. A large number of studies have confirmed that part of traditional Chinese medicine can reverse the chemotherapy resistance of OS cells by regulating the ABC transmembrane transport protein system. This article gives an overview of its related mechanisms and latest developments.
