Research Progress in Epigenetics of Pancreatitis-cancer Transformation

VernacularTitle:胰腺炎——癌转化的表观遗传学研究进展
Author: Ming YUE ¹ ; Haiyan XU ; Xiaofei ZHANG ; Liwei WANG
Author Information

1. Department of Oncology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Publication Type:Research Article
Keywords: Pancreatitis cancer; Pancreatitis-cancer transformation; DNA methylation; Histone modification; Non-coding RNA; Epigenetics
From: Cancer Research on Prevention and Treatment 2021;48(3):219-223
CountryChina
Language:Chinese
Abstract: Pancreatic ductal adenocarcinoma is one of the most common malignant tumors. Its early diagnosis and treatment are very difficult, and the mortality and recurrence rate are high. Chronic pancreatitis is an important risk factor for pancreatic cancer and has great potential to develop into pancreatic cancer. Therefore, it is necessary to study the mechanism of pancreatitis-cancer transformation for early diagnosis and treatment of pancreatic cancer. In recent years, more and more studies have shown that epigenetic modification plays an important role in pancreatitis-cancer transformation, and can provide an effective target for the diagnosis and treatment of pancreatic cancer. This article summarizes the role and mechanism of epigenetics in pancreatitis-cancer transformation based on the current research progress.