Correlation Between Dose Volume Parameters and Radiation Pneumonitis in Elderly Patients with Esophageal Cancer After Three-dimensional Conformal Radiotherapy
10.3971/j.issn.1000-8578.2021.20.1323
- VernacularTitle:老年食管癌患者三维适形放疗后发生放射性肺炎与剂量体积参数的相关性
- Author:
Sheng WANG
1
;
Cailian WANG
;
Lihua FAN
Author Information
1. Medical College of Southeast University, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
Elderly patient;
Esophageal cancer;
Radiation pneumonitis;
Three-dimensional conformal radiotherapy;
Dose-volume parameters
- From:
Cancer Research on Prevention and Treatment
2021;48(2):173-177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between ≥grade 2 radiation pneumonitis (RP) and dose volume parameters of elderly patients with esophageal cancer after three-dimensional conformal radiotherapy. Methods We collected the data of 250 elderly patients with esophageal cancer who received three-dimensional conformal radiotherapy from different medical centers. The clinical features of patients were analyzed by Chi-square test while dose volume parameters were analyzed by Logistic univariate and multivariate analyses. ROC curve was used to determine the best cut-off value. Results After three-dimensional conformal radiotherapy, 20% of patients developed ≥grade 2 RP. Univariate analysis showed that bilateral pulmonary V5, V10, V20, V30 and mean lung dose were associated with ≥grade 2 RP but multivariate analysis revealed that only V5 and V20 were independent relevant factors of RP. ROC curve indicated that the best cut-off value was V5 < 52.9% and V20 < 23.2%. Conclusion Bilateral pulmonary V5 and V20 are independently related to ≥grade 2 RP in elderly patients with esophageal cancer after 3-D conformal radiotherapy.
