Expressions of TP53, PDGF and EGFR in Primary Astrocytomas and Their Correlation with Clinicopathological Features and Prognosis
10.3971/j.issn.1000-8578.2021.20.0818
- VernacularTitle:原发星形细胞瘤中TP53、PDGF、EGFR的表达及与临床病理特征和预后的相关性
- Author:
Xiaoling SUN
1
;
Xiaojuan ZHANG
;
Qingquan ZHANG
;
Lei QIU
;
Linna WANG
;
Suping HOU
Author Information
1. Department of Pathology, Hengshui People's Hospital, Hengshui 053000, China
- Publication Type:Research Article
- Keywords:
TP53;
PDGF;
EGFR;
Primary astrocytoma;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2021;48(2):154-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of TP53, PDGF and EGFR in primary astrocytomas, and analyze their correlation with clinicopathological features and prognosis. Methods We analyzed retrospectively the clinicopathological data of 90 patients with primary astrocytoma. The expressions of TP53, PDGF and EGFR in primary astrocytoma tissue samples were detected by immunohistochemistry. The survival of patients was followed up and Cox regression analysis was used to determine the prognostic factors. Results TP53 was expressed in the nucleus, PDGF and EGFR were expressed in the cytoplasm and cell membrane. The positive expression rates of TP53, PDGF and EGFR were 58.89%, 51.11% and 48.89%, significantly higher than those in normal brain tissues (all P < 0.05); the positive expression rate of TP53 in patients with tumor size ≥3 cm was higher than that in patients with tumor size < 3 cm. The positive expression rates of TP53, PDGF and EGFR in patients with WHO stages Ⅲ-Ⅳ were higher than those in patients with WHO stageⅠ-Ⅱ(all P < 0.05); the survival time of patients with positive expression of TP53, PDGF and EGFR were shorter than those of negative expression (all P < 0.05). Cox regression analysis found that WHO staging, TP53, PDGF and EGFR were all factors influencing the prognosis of primary astrocytomas patients. Conclusion TP53, PDGF and EGFR are highly expressed in primary astrocytomas and closely related to tumor progression. They are factors that affect the prognosis of patients.
