Prognosis Analysis of Non-small Cell Lung Cancer with Diameter over 7.0 cm Based on SEER Database
10.3971/j.issn.1000-8578.2021.19.1587
- VernacularTitle:基于SEER数据库的肿瘤直径大于7.0厘米的非小细胞肺癌患者预后分析
- Author:
Tingting FENG
1
;
Zhongzhong CHEN
;
Wenjin YAN
;
Yuxiu WANG
;
Jun ZHANG
;
Xingxiang XU
;
Yong CHEN
;
Junjun YANG
;
Lingfeng MIN
Author Information
1. Department of Respiratory and Critical Care Medicine, Northern Jiangsu People's Hospital, The First Clinical College of Dalian Medical University, Clinical Medical College of Yangzhou University, Yangzhou 225001, China
- Publication Type:Research Article
- Keywords:
Tumor size;
NSCLC;
Surgery;
SEER database;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2021;48(1):49-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the mortality risk and evaluate the curative effects of surgery and non-surgery on NSCLC with diameter > 7.0 cm. Methods We collected the data of NSCLC patients with diameter > 7.0 cm from 2010 to 2015 from the SEER database. The 1, 2, 3-year survival rates were analyzed by life table method. Overall survival curve was estimated by Kaplan-Meier method. Univariate and multivariate Cox regression models were used to analyze the independent prognostic factors. Results The 1, 2, 3-year survival rates were 51.8%, 33.0% and 25.0%, respectively. In univariate and multivariate analyses, tumor size, N stage and treatment were the independent prognostic factors (P < 0.001). Conclusion Surgery is benefited for the prognosis of stage N0-N1 NSCLC patients with diameter > 7.0 cm. And for stage N2 NSCLC patients with diameter 7.0-9.0 cm, surgical treatment has advantages in improving the prognosis. Surgical and non-surgical patients with tumor diameter ≥9.0 cm or lymph node N3 stage have no statistically significant differences in prognosis. In addition, palliative treatment does not improve the prognosis of patients.
