Chinese Medicine Intervention on Deep Vein Thrombosis-related Signaling Pathways After Total Knee Arthroplasty： A Review
10.13422/j.cnki.syfjx.202202229
- VernacularTitle:中药干预全膝关节置换术后深静脉血栓信号通路研究进展
- Author:
Wen YAN
1
;
Xingwen XIE
2
;
Yubiao GU
3
;
Wenxia YU
1
;
Ningbo LEI
3
;
Cheng MA
1
;
Yaxiong GAO
1
;
Wenguang LI
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Affiliated Hospital of Gansu University of Chinese Medicine， Lanzhou 730000， China
3. Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730050， China
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
total knee arthroplasty;
deep vein thrombosis;
signaling pathway;
knee osteoarthritis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(20):214-220
- CountryChina
- Language:Chinese
-
Abstract:
Total knee arthroplasty， as a common treatment option for advanced knee osteoarthritis， can alleviate the clinical symptoms of patients. Deep vein thrombosis of the lower extremity is the most common complication of total knee arthroplasty. Previous studies have shown that the occurrence of deep vein thrombosis after total knee arthroplasty is mostly related to the overexpression of inflammatory factors in vivo. Nuclear transcription factor-κB， Toll-like receptor 4， phosphatidylinositol 3-kinase/protein kinase B， tumor necrosis factor， and nuclear transcription factor E2-related factor 2 are typical signaling pathways related to inflammation. Regulating the expression of the signaling pathways can intervene the formation of inflammatory factors. Inhibiting the formation of inflammatory factors can help suppress the activation of platelets， thereby blocking thrombosis. According to previous research， Chinese medicine monomers， Chinese medicine extract， and compound Chinese medicine prescriptions all directly or indirectly inhibit the expression of inflammatory factors by regulating the above signaling pathways， thereby suppressing the occurrence of deep vein thrombosis after total knee arthroplasty. Therefore， Chinese medicine can reduce postoperative complications and promote postoperative recovery of patients at low cost with small side effects. This article summarizes the research on Chinese medicine intervention on deep vein thrombosis-related signaling pathways after total knee arthroplasty， which is expected to lay a basis for the in-depth study and clinical application of Chinese medicine in deep vein thrombosis.
