Clinical Efficacy of Huanglian Jiedutang in Adjuvant Treatment of Acute Cerebral Infarction Complicated with Gastric Motility Disorder
10.13422/j.cnki.syfjx.20240594
- VernacularTitle:黄连解毒汤辅助治疗脑梗死急性期并发胃动力障碍的临床疗效
- Author:
Pengpeng AN
1
;
Yawen LAN
2
;
Huanhuan LIU
2
;
Chunyan WANG
2
;
Zhaokai GAO
2
;
Zeng ZHANG
2
;
Xiaoxuan KONG
2
;
Wenwen LI
2
;
Ming TANG
1
;
Zhizhen REN
3
Author Information
1. Qingdao Hiser Hospital Affiliated of Qingdao University[Qingdao Traditional Chinese Medicine (TCM)Hospital],Qingdao 266033,China
2. Shandong University of TCM,Jinan 250014,China
3. Shinan District Community Health Service Center,Qingdao 266073,China
- Publication Type:Journal Article
- Keywords:
Huanglian Jiedutang;
acute cerebral infarction;
gastric motility disorder;
electrogastrogram;
citrulline（CIT）;
motilin（MTL）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(20):81-87
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the clinical efficacy of Huanglian Jiedutang as an adjunctive treatment for acute cerebral infarction complicated with gastric motility disorder. MethodSixty patients with acute cerebral infarction complicated with gastric motility disorder with fire toxin syndrome were randomly divided into a western medicine control group （control group） and a traditional Chinese medicine （TCM） combined treatment group （observation group）， with 30 cases in each group. The control group received basic treatment for cerebral infarction and relevant western medical symptomatic treatment based on the patients' gastrointestinal symptoms. The observation group received Huanglian Jiedutang in addition to the treatment provided to the control group. The treatment course was 7 days. Neurological deficit scores and gastrointestinal dysfunction scores were assessed in both groups before treatment and on the 4th and 7th days of treatment. Gastrointestinal electrographic parameters， serum citrulline （CIT）， and motilin （MTL） levels were measured in both groups before treatment and on the 7th day of treatment. Clinical efficacy was compared between the two groups. ResultCompared with the baseline in both groups， the neurological deficit scores and gastrointestinal dysfunction scores were significantly reduced on the 4th and 7th days of treatment （P<0.05）. The reductions in these scores were more significant on the 7th day compared with those on the 4th day of treatment （P<0.05）. On the 4th and 7th days of treatment， the observation group showed a significantly greater reduction in neurological deficit scores and gastrointestinal dysfunction scores compared with the control group （P<0.05）. On the 7th day of treatment， compared with the baseline， both groups showed a significant increase in gastric antral and gastric body electric wave amplitudes as well as serum CIT and MTL levels （P<0.05）， and there were no statistically significant differences in the frequency of gastric antral and gastric body electric waves. On the 7th day of treatment， compared with the control group， the observation group had a significant increase in gastric antral and gastric body electric wave amplitudes as well as serum CIT and MTL levels （P<0.05）， and there were no statistically significant differences in the frequency of gastric antral and gastric body electric waves. After 7 days of treatment， the total effective rate in the observation group was 90.00% （27/30）， higher than 76.67% （23/30） in the control group， but the difference was not statistically significant. ConclusionAdjunctive treatment with Huanglian Jiedutang can effectively improve the symptoms of neurological function impairment and gastrointestinal dysfunction in patients with acute cerebral infarction complicated with gastric motility disorder， increase gastric antral and gastric body electric wave amplitudes， improve gastric motility disorder， and increase serum CIT and MTL levels， thereby improving the imbalanced secretion function of the gastrointestinal tract.
