Dengue Encephalopathy or Japanese Encephalitis? Co-Infection or Serologic Cross- Reactivity?
https://doi.org/10.47836/mjmhs.18.6.44
- Author:
Cheng Keat Moh
1
;
Calvin Ke Wen Wong
1
;
Hong Bee Ker
1
Author Information
1. Department of Internal Medicine, Hospital Raja Permaisuri Bainun, Jalan Raja Ashman Shah, 30450 Ipoh, Perak, Malaysia, Ministry of Health Malaysia
- Publication Type:Case Reports
- Keywords:
Dengue encephalopathy, Cross-reactivity, Co-infection, Japanese encephalitis
- From:Malaysian Journal of Medicine and Health Sciences
2022;18(No.6):344-346
- CountryMalaysia
- Language:English
-
Abstract:
Dengue infection has a wide clinical spectrum ranging from asymptomatic presentation to life-threatening severe
dengue with multiorgan failure, and increasingly recognized neurological presentation in the past decade. Japanese
encephalitis on the other hand is another common mosquitoes-borne flavivirus infection endemic in Southeast Asia,
which share some similar clinical features. We report a case of a 38-year-old male patient who presented to us with
complaints of fever and acute encephalitis syndrome with positive dengue NS1 antigen, and positive cerebrospinal
fluid serologies for both dengue and JE immunoglobulins. Magnetic Resonance Imaging findings were suggestive of
encephalitic changes. Co-infection and serology cross-reactivity of these two flaviviruses is not uncommon in countries where both dengue and Japanese encephalitis are endemic, and thus, the treating clinician should have a high
index of suspicion if clinical and serological evidence are present whilst treating the patient.
- Full text:11.2022my1394.pdf
